The primary difference between the two viral types is in the location where they typically establish latency in the body- their „site of preference.“ HSV-1 usually establishes latency in the trigeminal ganglion and produces most cold sores. HSV-2 usually sets up residence in the sacral ganglion at the base of the spine. From there, it recurs in the genital area. Symptoms of HSV infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. Lesions heal with a scab characteristic of herpetic disease. Sometimes the viruses cause very mild or atypical symptoms during outbreaks. HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of nerves. After the initial infection, some infected people experience sporadic episodes of viral reactivation. In an outbreak, the virus in a nerve cell becomes active and is transported via the nerve axon to the skin, where virus replication and shedding occur and cause sores.
AmpliSens® HSV I, II-FRT PCR kit is qualitative test and contains the Internal Control to control the extraction process of each sample and to identify possible reaction inhibition. Analytical sensitivity is 1 x 103 copies/ml.
AmpliSens® HSV-typing-FRT PCR kits are in vitro nucleic acid amplification tests for qualitative detection and differentiation of Herpes Simplex virus types 1 and 2 (HSV-1 and HSV-2). In the biological material (scrapes, swabs of urogenital tract mucous membranes; papules, vesicles, or ulcers fluid; urine sediment) by using of Real-Time PCR. Kits contain the Internal Control, used in the extraction procedure in order to control the extraction process of each sample and to identify possible reaction inhibition. Analytical sensitivity is 103 copies/ml.