Varicella zoster virus (VZV) is closely related to the herpes simplex viruses (HSV), sharing much genome homology. The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV, however there is no equivalent of HSV gD. VZV also fails to produce the LAT (latency-associated transcripts) that play an important role in establishing HSV latency (herpes simplex virus). VZV is known by many names such as chicken pox virus, varicella virus, zoster virus and human herpes virus type 3 or HHV-3. Varicella is chicken pox and zoster is shingles.
These are two different types of illnesses that manifest themselves through lesions, fever, and overall not feeling well. After having the chicken pox typically as a child, the virus lies dormant in the body before reoccurring into a viral infection. Only about twenty-five percent of adults are affected by the reactivation known as shingles. Both chicken pox and shingles are caused by the Varicella zoster igg which is a type of a herpes virus. Chicken pox is spread by human contact through the rash, sneezing, coughing or breathing. The contagious period appears two days before the rash appears to the day when the last lesion has crusted over. After the chicken pox the virus hibernates in the body’s nerve cells along the spine. When the virus in an adult decides to wake up due to stress, aging or a weaken immune system, it reappears as pain and a rash. The rash will usually last up to thirty days.
AmpliSens® VZV-FRT PCR kit is a qualitative test, containing Internal Control for detection of DNA extraction efficiency as well as amplification process. Analytical sensitivity is 500 copies/ml.