Candida sp. cause a wide spectrum of diseases, ranging from superficial mucocutaneous disease to invasive illnesses, such as hepatosplenic candidiasis, Candida peritonitis and systemic candidiasis. Local and systemic disease caused by Candida spp. has resulted in numerous new clinical syndromes, the expression of which depends primarily on the immune status of the host. Although Candida most frequently infects the skin and mucosal surfaces, it can cause systemic infections manifesting as pneumonia, septicemia or endocarditis in severely immunocompromised patients. There does not appear to be a significant difference in pathogenic the potential of different Candida strains, therefore establishment of infection appears to be determined by host factors and not by the organism itself. However, the ability to assume various forms may be related to the pathogenicity of the organism.
AmpliSens® Candida albicans-FRT PCR kits are qualitative tests and contain Internal Control which must be used in the extraction procedure in order to control the extraction process of each specimen and to identify possible PCR reaction inhibition.